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August 19, 2025BMC GastroenterologyOpen Access

Association between gastrointestinal disorders and sleep-related problems: the mediating effect of depression

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Authors

SYShicheng YeSLSui LiliXZXuan Zeng

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Overview

Observational analysis reveals associations between gastrointestinal disorders and sleep disorders, indicating depression’s mediating role.

Key Points

  • Individuals with gastrointestinal disorders have a 70% higher likelihood of sleep disturbances compared to those without GI issues.
  • Those affected by gastrointestinal disorders showed an increased risk of sleep disorders, with an adjusted odds ratio of 1.80.
  • Mediation analysis indicated that depression partially mediates the impact of gastrointestinal disorders on sleep trouble, sleep disorders, and sleep duration.
  • These findings suggest that addressing both gastrointestinal and psychological health may enhance sleep quality in affected individuals.

Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/68af35e3cf1dd9ea359ea0afhttps://doi.org/10.1186/s12876-025-04180-8
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  1. 1Association between gastrointestinal diseases and depression severity among middle-aged and older Chinese women: the mediating effect of sleep duration2026
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  3. 3Association of insomnia with anxiety might be greater than that of depression among patients with gastrointestinal cancer: a network analysis2026
  4. 4Examining Mediating Factors in the Relationship Between Sleep Disturbance and Symptoms in Adults with Inflammatory Bowel Disease2025
  5. 5Joint Association of Depression and Sleep Duration With All‐Cause and Cardiovascular Mortality: A Cross‐Sectional Study With Inflammation Mediation Analysis2025