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August 19, 2025Nutrition and DiabetesOpen Access

Kefir-derived exopolysaccharide ameliorates hyperglycemic control and beta cell integrity in a rat model of type 2 diabetes mellitus

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Authors

CYChih‐Ching YenCTChun‐Ming TsaiGCGary Ro‐Lin Chang

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Implication

Randomized trial shows kefir-derived exopolysaccharides enhance glucose uptake in diabetic rats, indicating effective nutraceutical management.

Key Points

  • High-dose kefir-derived exopolysaccharides significantly stabilize blood glucose levels in diabetic rats, reducing hyperglycemia.
  • GLUT2 protein expression and PI3k phosphorylation increased after KEPS treatment, enhancing glucose uptake.
  • This observational analysis used a rat model induced with streptozotocin and a high-fat diet to assess treatment.
  • Kefir-derived exopolysaccharides may offer a promising nutraceutical approach for diabetes management, requiring human validation.

Cite This Study

Yen et al. (2025) studied this question.

synapsesocial.com/papers/68af33efcf1dd9ea359e973ehttps://doi.org/10.1038/s41387-025-00388-5
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