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August 1, 2025The International Journal of NeuropsychopharmacologyOpen Access

The N-3 Polyunsaturated Fatty Acids Supplementation to Prevent Depression Recurrence in Patients With Late-Life Depression: A 52-Week Double-Blind, Placebo-Controlled Trial

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Authors

YCYu‐Fan ChengWCW-Y- ChenCCChong‐Chi Chiu

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Overview

Randomized controlled trial shows n-3 PUFAs significantly reduce depression recurrence in patients, indicating preventive benefits.

Key Points

  • N-3 PUFAs significantly reduced the risk of depression recurrence in patients with late-life depression.
  • The study had a Hazard Ratio of 0.295 (p = 0.037), underscoring n-3 PUFAs' protective effect.
  • A double-blind, randomized, controlled trial was conducted over 52 weeks with 39 euthymic patients.
  • Findings highlight the potential role of n-3 PUFAs in depression prevention, though no significant impact on depressive symptoms was noted.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/68af33efcf1dd9ea359e9563https://doi.org/10.1093/ijnp/pyaf052.162
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Polyunsaturated Fatty Acids (Ω-3 Pufa) in the Prevention of Postpartum Depression2025
  2. 2Omega-3 and Postpartum Depression: Assessing the Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Preventing Postpartum Depression2025
  3. 3A plasma protein profile of antidepressant response to omega-3 fatty acids2025 · 2 citations
  4. 4Omega-3 Polyunsaturated Fatty Acids and Cognitive Decline in Adults with Non-Dementia or Mild Cognitive Impairment: An Overview of Systematic Reviews2025
  5. 5Exploring the Preventive Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation on Global Cognition: A Systematic Review and Meta-Analysis of Cognitively Unimpaired Older Adults2025