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August 18, 2025CancersOpen Access

Targeting Macrophages in Glioblastoma: Current Therapies and Future Directions

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Authors

GPGiovanni PennisiFVFederico ValeriBBBenedetta Burattini

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Overview

Systematic review reports on targeting macrophages in glioblastoma, suggesting combination therapies may enhance treatment efficacy.

Key Points

  • Targeting tumor-associated macrophages may improve treatment responses in glioblastoma, sparking future research initiatives.
  • Review highlights 30 studies focusing on different therapeutic strategies aimed at macrophages in glioblastoma treatment.
  • Analysis of therapeutic approaches included evaluating inhibitory and enhancing strategies targeting macrophages' roles in tumors.
  • Challenges like heterogeneity and blood-brain barrier interactions must be addressed for successful clinical applicability.

Cite This Study

Pennisi et al. (2025) studied this question.

synapsesocial.com/papers/68af33d5cf1dd9ea359e8628https://doi.org/10.3390/cancers17162687
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tumor-Associated Macrophages in Glioblastoma: Mechanisms of Tumor Progression and Therapeutic Strategies2025
  2. 2The Immunosuppressive Microenvironment of Glioblastoma: Mechanisms, Clinical Challenges, and Future Directions2025
  3. 3EP08.01 THE IMMUNE LANDSCAPE OF BRAIN TUMORS: IMPLICATIONS FOR NEUROIMMUNOLOGY AND NEURO-ONCOLOGY THERAPIES2025
  4. 4Harnessing innate immunity against glioblastoma microenvironment2025 · 13 citations
  5. 5Targeting the Tumor Micro-environmental in Glioblastoma: Barriers, Pathways, and Experimental Strategies2026