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August 1, 2025The International Journal of NeuropsychopharmacologyOpen Access

Cannabidiol Mitigates Cognitive Deficits in a Mouse Model of Alzheimer’s Disease

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Authors

YCYC ChenYHY-H HsiaoSHSusan C. Hu

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Overview

Observational analysis shows improved cognitive performance in an Alzheimer's disease model, suggesting CBD may serve as a viable therapeutic agent.

Key Points

  • CBD treatment significantly improved cognitive performance in 3xTg-AD mice, compared to controls, with notable results in the Morris water maze and object location test.
  • Mice treated with CBD showed increased time spent in the target zone and a higher object discrimination index, indicating cognitive enhancement from the treatment.
  • The analysis involved a mouse model (3xTg-AD) compared to cognitive controls, using behavioral tests for evaluation.
  • These results indicate that CBD has therapeutic potential in mitigating cognitive deficits in Alzheimer's disease models, warranting further investigation in clinical settings.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af2ee5cf1dd9ea359e671ahttps://doi.org/10.1093/ijnp/pyaf052.192
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cannabidiol improves short-term memory in a Streptozotocin-induced animal model of Alzheimer’s disease2025
  2. 2Cannabidiol improves learning and memory deficits and alleviates anxiety in 12-month-old SAMP8 mice2025 · 6 citations
  3. 3Cannabidiol prevents cognitive and social deficits in a male rat model of Alzheimer’s disease through CB1 activation and inflammation modulation2025 · 12 citations
  4. 4Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment2025
  5. 5Cannabidiol and Alzheimer Disease: A Comprehensive Review and In Silico Insights Into Molecular Interactions2025 · 3 citations