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August 18, 2025International Journal of Translational MedicineOpen Access

Comparison of the Differing Impacts of Lowered N-Acetylglucosaminyltransferase-Ia/b Activity on Motor and Sensory Function in Zebrafish

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Authors

MHM. Kristen HallCHCody J. HatchettHKHaris Ali Khan

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Overview

Comparison shows altered motor and sensory function in mutant zebrafish, indicating N-glycan processing is crucial for nervous system health.

Key Points

  • Mutant zebrafish with altered N-glycan processing exhibited impaired motor and sensory functions into adulthood, indicating long-term impacts.
  • The mgat1a−/− zebrafish showed higher levels of oligomannosylated proteins compared to Wt AB in various tissues, demonstrating a knockdown effect.
  • CRISPR Cas9 engineering created mutant zebrafish models to study the role of N-glycans in motor and sensory functions.
  • These findings underscore the importance of complex N-glycans for maintaining nervous system health and function.

Cite This Study

Hall et al. (2025) studied this question.

synapsesocial.com/papers/68af2edecf1dd9ea359e6430https://doi.org/10.3390/ijtm5030036
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