August 18, 2025Discover OncologyOpen Access

CD99 is a potential diagnostic and immunological biomarker in pan-cancer

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CD99 expression is significantly higher in numerous common cancers, revealing its potential in diagnostics.
Genetic alterations of CD99 primarily involve deletions, particularly in sarcoma, indicating a unique cancer association.
Bioinformatics techniques enabled an extensive analysis of CD99's relationship with immune cell infiltration and checkpoints.
Understanding CD99's role in epithelial-mesenchymal transition may aid in developing targeted therapies against drug resistance.

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Comprehensive analysis finds CD99 upregulated in multiple cancer types, suggesting its role in diagnostics and prognosis.

Jiang et al. (2025) studied this question.

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