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August 14, 2025Brain

Brain signatures of nociplastic pain: Fibromyalgia Index and descending modulation at population level

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Authors

EKEoin KelleherFLFrederik LangeVWVishvarani Wanigasekera

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Overview

Observational analysis reveals FMI scores affect connectivity in brain circuits of chronic pain, suggesting implications for nociplastic pain research.

Key Points

  • Altered structural connectivity in chronic pain individuals was significantly associated with Fibromyalgia Index scores, indicating a biological link to nociplastic pain.
  • FMI scores showed specific associations with PAG-amygdala and PAG-hypothalamus connectivity, highlighting distinct brain changes relevant to pain perception.
  • Functional and structural connectivity were assessed using multimodal neuroimaging in a large sample of over 40,000 participants from the UK Biobank.
  • Findings support the specificity of the Fibromyalgia Index as a biomarker for nociplastic pain, emphasizing its neurobiological relevance in chronic pain assessment.

Cite This Study

Kelleher et al. (2025) studied this question.

synapsesocial.com/papers/68af2d7ccf1dd9ea359e58eehttps://doi.org/10.1093/brain/awaf307
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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