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August 15, 2025

Identifying the optimal combinations of modifiable dementia risk factors to target in multidomain intervention - Three-year longitudinal findings from the Canadian longitudinal study on aging.

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Authors

SSSurim SonMSMark SpeechleyGZGuangyong Zou

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Overview

Longitudinal analysis identifies key combinations affecting cognition in adults, suggesting targeted interventions.

Key Points

  • Hearing loss and physical inactivity combined led to a significant cognitive decline over three years, impacting global cognition.
  • The study identified specific combinations, such as dyads and triads of risk factors, which significantly affect cognition.
  • Analysis involved 30,097 adults aged 45 to 85, evaluating their cognitive changes through linear mixed effect models.
  • Targeting auditory health and physical exercise may enhance the efficacy of multidomain interventions for dementia.

Cite This Study

Son et al. (2025) studied this question.

synapsesocial.com/papers/68af2d6fcf1dd9ea359e4fbchttps://doi.org/10.1016/j.tjpad.2025.100321
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multimorbidity in dementia: Current perspectives and future challenges2025
  2. 2Prevalence and co-occurrence of dementia risk factors in Denmark: A nationwide study2025 · 2 citations
  3. 3Neurophysiological correlates of modifiable dementia risk factors in cognitively unimpaired older adults2025
  4. 4Psychosocial Hierarchies of Modifiable Risk for Alzheimer’s Disease: A Networks Analysis2025
  5. 5Relationship Between Clusters of Multimorbidity and Dementia Risk: A Systematic Review2025