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August 8, 2025Frontiers in ImmunologyOpen Access

Unraveling the role of chemokines in cutaneous T-cell lymphoma: expression levels at different stages

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Authors

AGAlba GuglielmoCZCorrado ZengariniFTFederica Tugnoli

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Overview

This review demonstrates altered expression of chemokines in cutaneous T-cell lymphoma, suggesting new therapeutic targets.

Key Points

  • Altered chemokine expression contributes to disease progression in cutaneous T-cell lymphoma, especially in Mycosis fungoides and Sezary syndrome.
  • Chemokine receptors like CCR4 and CCR7 show distinct expression patterns linked to tumor evolution and immune evasion.
  • The review explores the shift from Th1 to Th2 immune profiles, emphasizing their relevance in tumor progression.
  • Understanding the dual role of chemokines may lead to novel therapies and improved outcomes for patients with CTCL.

Cite This Study

Guglielmo et al. (2025) studied this question.

synapsesocial.com/papers/68af2b63cf1dd9ea359e4be4https://doi.org/10.3389/fimmu.2025.1646669
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune pathways, current and potential therapies in Mycosis fungoides and Sezary syndrome2025 · 2 citations
  2. 2Clinical and Prognostic Features of Erythrodermic Cutaneous T-Cell Lymphoma: A Retrospective Study of 35 Patients2025
  3. 3Diagnostic and therapeutic impact of miR-142, miR-146a, and miR-155 on cutaneous T-cell lymphoma2025 · 1 citations
  4. 4Heterogeneity of circulating CD57+ cytotoxic cell subsets across disease stage and aggressiveness in cutaneous T cell lymphoma2025
  5. 5Mycosis fungoides: a review2025 · 11 citations