Clinical Management of Asthma: New Insights Overview

Significant advancements in asthma management have been observed in recent years. New major findings in the pathogenesis of asthma have focused on epigenetics, the innate cellular compartment, and the distinctive immune system. The accurate immunology process was complemented with innovative techniques and the use of artificial intelligence (AI). Numerous human trials and valuable evidence have highlighted asthma treatments and informed modifications in many guidelines for asthma, such as GINA, Expert Panel Report 3, and the guidelines of ERS/ATS on severe asthma, as well as the development of novel guidelines like EAACI for the use of biologicals in severe asthma. Asthma treatment has been put forward with its integration within the wider milieu of Planetary Health. Recently, progress has been meaningful regarding enhanced knowledge about the processes underlying responses/non-responses to new therapeutic approaches and asthma phenotypes. This review recapitulates current information on the international guidelines, diagnosis and therapeutic approaches for asthma management.