August 21, 2025Open Access

Evidence-based answers to clinical controversies in the management of severe asthma

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Effective treatment of severe asthma requires careful selection of biologic therapy, based on patient biomarkers and profile.
Emerging evidence suggests precision medicine improves outcomes, with targeted biologics benefiting high-type 2 asthma patients significantly.
Recent findings point to distinct inflammatory profiles in severe asthma, emphasizing the need for personalized management strategies.
Current challenges include determining optimal treatment duration and safe strategies for de-escalation in asthma management.

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Review demonstrates the role of biologic therapies in severe asthma, highlighting challenges in treatment personalization.

El‐Qutob et al. (2025) studied this question.

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