DMP1-mediated transformation of DPSCs to CD31+/CD144+ cells demonstrate endothelial phenotype both in vitro and in vivo

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DMP1 transforms dental pulp stem cells into endothelial cells expressing CD31 and CD144, suggesting therapeutic avenues for tissue repair.

The CD31+/CD144+ fraction retained functional endothelial characteristics, facilitating neovascularization.
In vivo analysis revealed that DMP1-stimulated ECs expressed vasculogenic markers and improved blood vessel formation.
Culturally specific methods using HUVEC ECM and DMP1 were applied to enable conversion of DPSCs into endothelial cells.
This strategy may have significant therapeutic implications for enhancing tissue repair and regeneration.

Ganapathy et al. (2025) studied this question.

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DMP1 transforms dental pulp stem cells into endothelial cells expressing CD31 and CD144, suggesting therapeutic avenues for tissue repair.