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August 13, 2025Cell Communication and SignalingOpen Access

Activation of integrin signaling up-regulates pro-inflammatory cytokines in JAK2-V617F positive hematopoietic cells

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Authors

CBConny K. BaldaufCFCorinna FahldieckAAAlexa Angenstein

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Overview

Observational analysis shows elevated pro-inflammatory cytokines in JAK2-V617F hematopoietic cells, highlighting integrin signaling's role in MPN.

Key Points

  • Integrin activation increases pro-inflammatory cytokines, including il-1α and il-6, in hematopoietic cells.
  • JAK2-V617F mutation amplifies integrin-induced cytokine responses in 32D myeloid progenitor cells.
  • Western blot and qPCR were used to analyze signaling pathways and mRNA expression of inflammatory cytokines.
  • Blocking integrin binding in JAK2-V617F mice reduces elevated il-1α levels, suggesting therapeutic potential.

Cite This Study

Baldauf et al. (2025) studied this question.

synapsesocial.com/papers/68a34d8c234c60ad5c20aba1https://doi.org/10.1186/s12964-025-02358-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The V617F mutation in JAK2 renders myeloid cells more sensitive to IL-6-mediated gp130 signaling2025
  2. 2Association of the composition of the bone marrow tumor microenvironment in BCR::ABL1-negative myeloproliferative neoplasms with IFN-γ signaling and driver mutations2025 · 4 citations
  3. 3Disruption of IL-10 receptor signaling promotes hematopoietic stem cell exhaustion and clonal expansion of JAK2V617F mutant cells during inflammatory stress2025 · 1 citations
  4. 4Platelet priming in MPN triggers pro-thrombotic intermediate affinity state in αIIbβ3 integrin2025 · 1 citations
  5. 5HMGA1 chromatin regulators drive transcriptional networks involved in megakaryocyte expansion, fibrosis, and sensitivity to interferon signaling in JAK2-V617F MPN2025