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August 7, 2025LeukemiaOpen Access

Association of the composition of the bone marrow tumor microenvironment in BCR::ABL1-negative myeloproliferative neoplasms with IFN-γ signaling and driver mutations

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Authors

MBMarcus BauerCVChristoforos VaxevanisNJNadja Jäkel

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Overview

Observational study finds increased IFN-γ signaling in JAK2-mutated MPN patients, highlighting its role in tumor microenvironment and outcomes.

Key Points

  • BCR::ABL1-negative myeloproliferative neoplasms (MPN) show intrinsic activation of IFN-γ signaling related to patient prognosis.
  • Analysis of 265 bone marrow biopsies revealed a significant correlation between JAK2 mutations and IFN-γ signaling components.
  • A favorable prognostic cluster with high IFN-γ signaling and tumor infiltrating lymphocytes (TILs) was identified among JAK2-mutated patients.
  • Cox regression analysis determined TILs as the most significant prognostic marker for outcomes in MPN.

Cite This Study

Bauer et al. (2025) studied this question.

synapsesocial.com/papers/689521e49f4f1c896c427fd4https://doi.org/10.1038/s41375-025-02706-3
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