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August 6, 2025˜The œNephron journals/Nephron journals

Clinical trials for developing treatment and early diagnostic methods for chronic active antibody-mediated rejection in kidney transplantation —A review

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Authors

KHKiyohiko Hotta

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Overview

A review highlights methods for diagnosing chronic active antibody-mediated rejection in kidney transplant patients, indicating a need for effective treatments.

Key Points

  • The majority of long-term kidney transplant failures are due to chronic active antibody-mediated rejection (CAAMR).
  • Current research aims at identifying biomarkers in blood and urine for early diagnosis of CAAMR.
  • Various therapeutic approaches have been explored, but no effective treatment for CAAMR has been established.
  • The need for new diagnostic methods to enhance early detection of CAAMR is crucial as existing methods focus mainly on acute rejection.

Cite This Study

Kiyohiko Hotta (2025) studied this question.

synapsesocial.com/papers/689a0f99e6551bb0af8d15eehttps://doi.org/10.1159/000547781
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibody-Mediated Rejection in Kidney Transplantation: Immunopathogenesis, Innate–Adaptive Crosstalk, and Therapeutic Advances2025 · 2 citations
  2. 2Novel Biomarkers for Rejection in Kidney Transplantation: A Comprehensive Review2025 · 8 citations
  3. 3Noninvasive Diagnosis of Kidney Allograft Rejection2025 · 4 citations
  4. 4Development of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients2025
  5. 5High-resolution multiplexed antibody-omics and interpretable machine learning unveil novel pathogenic mechanisms in kidney transplant rejection2025