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August 4, 2025Clinical Transplantation

Emerging Therapeutic Strategies for Renal Ischemia‐Reperfusion Injury in Kidney Transplantation: Progress and Challenges—A Systematic Review

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Authors

SKSohail KhanDZDayanna ZuluagaLRLloyd E. Ratner

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Overview

Systematic review evaluates investigational therapies for renal ischemia-reperfusion injury in kidney transplantation, indicating challenges in clinical translation.

Key Points

  • Ischemia-reperfusion injury contributes significantly to delayed graft function and allograft loss during transplantation.
  • A systematic search identified 43 eligible reports on pharmacologic interventions for renal ischemia-reperfusion injury.
  • Recent therapeutic strategies include alkaline phosphatase and MSC-derived exosomes, which are in early development stages.
  • Future research should focus on harmonized models and biomarkers for effective integration of therapies into kidney transplant care.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/689a0f8de6551bb0af8d0ee6https://doi.org/10.1111/ctr.70263
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protective role of exosomes in renal ischemia-reperfusion injury: a systematic review and meta-analysis2025
  2. 2Exploring the Immunological Landscape of Ischemia/Reperfusion Injury and Graft Rejection in Kidney Transplantation: Shared Mechanisms and Insights2025 · 9 citations
  3. 3Bilateral and Unilateral Renal Ischemia‐Reperfusion Injury Model in Rats2025
  4. 4Integrating Multi‐Omics Data Using Machine Learning to Explore New Therapeutic Targets for Acute Kidney Injury2025
  5. 5Mitochondrial subtypes in renal ischemia reperfusion injury guide delayed graft function and Long-Term graft prediction2025