September 10, 2025Frontiers in PharmacologyOpen Access

Protective role of exosomes in renal ischemia-reperfusion injury: a systematic review and meta-analysis

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Discussion

Systematic review finds exosome therapy improves outcomes in renal ischemia-reperfusion injury models, suggesting therapeutic potential.

Exosome treatment significantly improves renal function and reduces cellular damage in renal ischemia-reperfusion injury models.
Subgroup analysis indicates that exosomes derived from mesenchymal stem cells are more effective than those from fibroblasts in renal protection.
The systematic review analyzed data from 19 controlled preclinical studies involving 245 rodents to evaluate exosome therapy.
Further investigation is needed to optimize exosome therapeutic protocols for faster clinical application.

Wang et al. (2025) studied this question.

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