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August 4, 2025Pharmacogenomics

Evidence level for pharmacogenetic testing in antidepressant treatment: a systematic review

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Authors

ETEmytis TavakoliLMLeen MagarbehSESamar S. M. Elsheikh

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Overview

Systematic review reveals pharmacogenetic testing improves treatment response in depression, suggesting its value in personalized medicine.

Key Points

  • Pharmacogenetic testing improves antidepressant response rates in patients with depression.
  • Studies showed higher remission rates at 8 and 12 weeks compared to treatment-as-usual (TAU).
  • Randomized controlled trials and meta-analyses assessed the effectiveness of CYP2D6 and CYP2C19 testing.
  • Findings indicate that pharmacogenetic testing is crucial for achieving earlier remission in depression.

Cite This Study

Tavakoli et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0908https://doi.org/10.1080/14622416.2025.2541402
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative effectiveness of pharmacogenomic-guided versus unguided antidepressant treatment in major depressive disorder: new insights from subgroup and cumulative meta-analyses2025 · 9 citations
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  3. 3Meta-analysis of Response and Remission Outcomes With a Weighted Multigene Pharmacogenomic Test for Adults With Depression2025 · 10 citations
  4. 4Efficacy of pharmacogenetic (PGx)-guided antidepressant treatment on functional outcomes and quality of life in adults with anxiety and affective disorders: A systematic review and meta-analysis2025 · 5 citations
  5. 5Pharmacogenetic Implications for Antidepressant Therapy in Major Depression: A Systematic Review Covering 2019–20242025 · 6 citations