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July 30, 2025Journal of Clinical MedicineOpen Access

Pharmacogenetic Implications for Antidepressant Therapy in Major Depression: A Systematic Review Covering 2019–2024

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Authors

AFAnna FornagueraMMMarta Miarons

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Overview

Systematic review shows pharmacogenetic factors impact antidepressant response in major depression, suggesting personalized prescribing may enhance outcomes.

Key Points

  • Genetic variants like CYP2C19 and CYP2D6 significantly influence antidepressant efficacy and safety.
  • Among 793 abstracts screened, 29 studies with nearly 40,000 participants were analyzed for pharmacogenetic data.
  • Poor metabolizers of CYP2C19 had higher SSRI plasma levels, leading to more adverse effects.
  • Combinatorial pharmacogenetic testing was more predictive of treatment outcomes than single-gene testing.

Cite This Study

Fornaguera et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cedd8https://doi.org/10.3390/jcm14145102
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