Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 2, 2025

Generation of effector CD4+ T cells from Human iPSC

View Full Paper
Ask AI
Bookmark
Share

Authors

JAJulian AmiraultDHDar HeinzeMYMengwei Yang

Discussion

Loading...

Member takes

Overview

Research finds Notch ligand withdrawal enhances CD4+ T cell maturation from iPSC, suggesting potential for cancer and autoimmune treatments.

Key Points

  • MAIN FINDING: Notch ligand withdrawal is crucial for the maturation of functional CD4+ T cells from iPSCs.
  • KEY EVIDENCE: iCD4+ T cells expressed Th1 cytokine signatures and other cytokines like IL-4 and IL-8.
  • APPROACH: Functional analyses used CyTOF cytokine staining and single-cell RNA sequencing on iCD4+ T cells.
  • SIGNIFICANCE: This method could lead to accessible CD4+ T cell therapies for cancer and autoimmune diseases.

Cite This Study

Amirault et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0446https://doi.org/10.1101/2025.08.01.667959
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Generation of iNKT cells with hematopoiesis-promoting properties from human iPSCs2025
  2. 2Engineering Intracellular Signaling Domains to Drive CAR-T Cell Differentiation from Pluripotent Stem Cell 28652025
  3. 3Molecular controls of T-lineage differentiation and thymus engraftment from human induced pluripotent stem cells 20562025
  4. 4Induced Pluripotent Stem Cell-Based Cancer Immunotherapy: Strategies and Perspectives2025 · 5 citations
  5. 5The Generation of iPSCs Expressing Interferon-Beta Under Doxycycline-Inducible Control2025