The Generation of iPSCs Expressing Interferon-Beta Under Doxycycline-Inducible Control

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This research generates interferon-beta-expressing iPSCs using CRISPR/Cas9 technology, suggesting a model for therapeutic investigations.

iPSCs overexpressing interferon-beta showed significant increases in expression levels after doxycycline treatment.
Using CRISPR/Cas9, three iPSC lines with controlled interferon-beta expression were successfully generated.
The pluripotency of the newly created iPSC lines was confirmed through multiple marker assays and differentiation capabilities.
This model provides an innovative way to study the therapeutic effects of interferon-beta in diverse cellular contexts.

Шевелева et al. (2025) studied this question.

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