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July 31, 2025Health Science ReportsOpen Access

Association of Deficiency in Vitamin D, Vitamin E, and Selenium Levels With Premature Ovarian Insufficiency: A Systematic Review

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Authors

FPFarideh PargarMFMaryam FarjamfarSGShahrbanoo Goli

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Overview

Systematic review shows association of vitamin D, E, and selenium with ovarian reserve in women, suggesting potential preventive strategies.

Key Points

  • The review assessed the role of vitamins D, E, and selenium in relation to premature ovarian insufficiency (POI).
  • Of 2067 studies, 12 were included, involving 521 women, examining antioxidant vitamins and their effect on ovarian reserve.
  • Findings indicated that lower levels of vitamins D, E, and selenium correlate with reduced ovarian reserve markers in women.
  • Potential vitamin supplementation could improve AMH levels and lower FSH, offering new approaches to manage POI.

Cite This Study

Pargar et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf72bhttps://doi.org/10.1002/hsr2.71136
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Excessive Vitamin E Supplementation: Implications for Ovarian Physiology and Reproductive Health2026
  2. 2Correlation between Estrogen Metabolites and Antioxidant Defense Systems in Premenopausal and Postmenopausal Women. A Clinical Study2023
  3. 3A Symbiotic Relation Between Anti-Mullerian Hormone (AMH) and Vitamin D in Polycystic Ovary Syndrome (PCOS): A Meta-Analysis and Systematic Review2025
  4. 4The effects of androgen therapy in women with premature ovarian insufficiency: A systematic review2025
  5. 5Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo development2025