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July 30, 2025Open Access

A Supra-Physiological Dose of 2-Hydroxyestradiol Impairs Meiotic Progression and Developmental Competence of Mouse Antral Oocytes

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Authors

VMValeria MericoPRPaola RebuzziniMZMario Zanoni

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Overview

Experiment reveals that elevated 2-hydroxyestradiol levels impair meiotic progression and developmental competence of mouse oocytes, indicating potential risks to fertility.

Key Points

  • Exposure to supra-physiological doses of 2-hydroxyestradiol impaired mouse oocyte maturation and development.
  • Doses of 0.50 and 5.00 µM 2-hydroxyestradiol significantly reduced blastocyst formation rates after fertilization.
  • Morphometric analysis revealed defects in first polar body morphology and asymmetric division during meiosis.
  • Findings suggest that altered cytoskeletal dynamics impact oocyte quality and embryonic viability in mice.

Cite This Study

Merico et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cf01ahttps://doi.org/10.20944/preprints202507.2319.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of estradiol on in vitro maturation of immature oocytes in cyclophosphamide-induced premature ovarian failure in NMRI mice: An experimental study2025
  2. 2Excessive Vitamin E Supplementation: Implications for Ovarian Physiology and Reproductive Health2026
  3. 3An Exploratory Study on Two Exogenous Estrogenic Metabolites (EDMs): Their Effects In Vitro and on Oophorectomized Female Rats2026
  4. 4Modulation of sperm function by estrogen and progesterone using in vitro experiments: A systematic review2025
  5. 5Vaginal microbiota alterations under supraphysiological estradiol state during in vitro fertilization-embryo transfer (IVF-ET) and the association with reproductive outcomes2025