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August 12, 2025International Journal of Reproductive BioMedicine (IJRM)Open Access

Effect of estradiol on in vitro maturation of immature oocytes in cyclophosphamide-induced premature ovarian failure in NMRI mice: An experimental study

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Authors

YSYasaman SohaniKharazmi UniversityMAMahnaz AzarniaKharazmi UniversityHZHadis ZeinaliKharazmi University

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Implication

Experimental study shows estradiol supplementation improves immature oocyte maturation in NMRI mice with premature ovarian failure, suggesting potential fertility therapies.

Key Points

  • Estradiol supplementation improved oocyte maturation, with a significance of p < 0.0001.
  • The lowest percentage of immature oocytes was found in control groups, while highest in sham (76.25%).
  • Experimental analysis indicated that estradiol doses inversely affected immature oocyte maturation rates.
  • Findings suggest that 1.5 μg/ml estradiol significantly enhances oocyte maturation in premature ovarian failure models.

Cite This Study

Sohani et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d64771049https://doi.org/10.18502/ijrm.v23i5.19263
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