July 30, 2025Physiological Reviews

Proglucagon-derived Peptides: Human Physiology and Therapeutic Potential

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Authors

LGLærke S. GasbjergUniversity of Copenhagen CNCasper K. NielsenUniversity of Copenhagen MSMalte Palm SuppliUniversity of Copenhagen

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Implication

Clinical review explores proglucagon-derived peptides' impact on metabolism and appetite regulation, highlighting therapeutic applications in various diseases.

Key Points

Proglucagon-derived peptides affect glucose, lipid, and protein metabolism, highlighting their physiological significance.
GLP-1 receptor agonists are pivotal in managing type 2 diabetes and obesity by reducing appetite and lowering glucose.
GLP-2 analogues provide focused treatment options for short bowel syndrome, addressing nutrient absorption issues.
The exploration of mono- and multi-receptor agonists suggests future therapeutic innovations in metabolic and gastrointestinal disorders.

Cite This Study

Gasbjerg et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cedc1 https://doi.org/10.1152/physrev.00057.2024

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Implication

Clinical review explores proglucagon-derived peptides' impact on metabolism and appetite regulation, highlighting therapeutic applications in various diseases.

Proglucagon-derived Peptides: Human Physiology and Therapeutic Potential

Discussion

Member takes

Implication

Key Points

Cite This Study

Proglucagon-derived Peptides: Human Physiology and Therapeutic Potential

Discussion

Member takes

Implication

Key Points

Cite This Study

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