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July 29, 2025Current Issues in Molecular BiologyOpen Access

Astragaloside IV Ameliorates Cerebral Ischemic-Reperfusion Injury via Improving Mitochondrial Function and Inhibiting Neuronal Apoptosis

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Authors

THTao HeXZXiaohong ZhouXWXiaorong Wang

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Overview

Astragaloside IV improves outcomes in cerebral ischemic-reperfusion injury, indicating its therapeutic potential.

Key Points

  • AS-IV shows neuroprotective effects in cerebral ischemic-reperfusion injury by enhancing mitochondrial function.
  • Treatment with AS-IV significantly reduces infarct volume and improves neurological function in a rat model.
  • Molecular assays demonstrate AS-IV upregulates PINK1/Parkin while modulating apoptosis markers Bcl-2 and BAX.
  • Identifying AS-IV's high affinity binding with PINK1/Parkin paves the way for its clinical application in brain injury.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8ceca8https://doi.org/10.3390/cimb47080597
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Astragaloside IV Attenuates Myocardial Ischemia‐Reperfusion Injury via Suppression of the NOX4/ROS Axis: Mechanistic Insights From In Vivo and In Vitro Models2026
  2. 2Astragaloside IV inhibits MAPK pathway and promotes mitochondrial autophagy in rats with heart failure2025
  3. 3Anemoside B4 mitigates endoplasmic reticulum stress-induced apoptosis post cerebral ischemia/reperfusion injury in rats.2025
  4. 4Astragaloside IV alleviates hypoxic pulmonary hypertension by inhibiting RELM-β to reduce PINK1/Parkin-mediated mitophagy in pulmonary artery smooth muscle cells (PASMCs).2025
  5. 5Astragaloside IV Improves Cognitive Impairment by Reducing β-Amyloid and Tau Protein Deposition in Hippocampal Tissue of db/db Mice: A PET/CT Imaging-Based Study.2025 · 1 citations