A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics

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Discussion

This review examines drug repurposing and pharmacological pleiotropy via thermodynamics, indicating new insights into drug development.

Drug repurposing emerges as a vital aspect of drug development in response to high therapeutic demand.
Pharmacological pleiotropy provides a structured framework for understanding the complexities of drug repurposing.
Insights from thermodynamics, including Gibbs free energy, are essential in delineating the repurposing process.
Leveraging artificial intelligence could further elucidate links between information theory, statistical mechanics, and drug discovery.

Head et al. (2025) studied this question.

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