August 19, 2025Open Access

Data-driven strategies for drug repurposing

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Comparative analysis identifies physicochemical properties in approved drugs, suggesting new therapeutic potential for repurposing.

The study provides a structured framework for assessing drug candidates, highlighting drug repurposing as a promising strategy in drug discovery.
Evaluating data from ChEMBL, BindingDB, and GtoPdb revealed 817 approved drug indications across 28 therapeutic groups.
An analysis of key physicochemical descriptors established benchmarks to prioritize compounds for specific indications.
A novel computational pipeline predicts repurposing opportunities for FDA approved drugs in major cancer types, enhancing their therapeutic use.

Savander et al. (2025) studied this question.

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