July 24, 2025

Preclinical evaluation of 18FAlF-FAPI-74 for PET imaging to study cancer-associated fibroblast responses to radiotherapy

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KLKristin Lode SKSindhu Kancherla YGYngve Guttormsen

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Implication

Preclinical evaluation of PET imaging shows radiotherapy impacts cancer-associated fibroblasts, suggesting FAP-specific tracers may serve as biomarkers.

Key Points

MAIN FINDING: Radiotherapy may moderately increase the population of FAP+ cancer-associated fibroblasts in tumors.
KEY EVIDENCE: The 2x6 Gy radiation regimen led to a two-fold increase in PET signal in tumor imaging.
APPROACH: The study utilized PET imaging with the [18F]AlF-FAPI-74 tracer using murine tumor models.
SIGNIFICANCE: Monitoring FAP+ cells offers insights into the tumor microenvironment and therapeutic responses.

Cite This Study

Lode et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8cdf59 https://doi.org/10.21203/rs.3.rs-7065428/v1

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Implication

Preclinical evaluation of PET imaging shows radiotherapy impacts cancer-associated fibroblasts, suggesting FAP-specific tracers may serve as biomarkers.

Preclinical evaluation of 18FAlF-FAPI-74 for PET imaging to study cancer-associated fibroblast responses to radiotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Preclinical evaluation of 18FAlF-FAPI-74 for PET imaging to study cancer-associated fibroblast responses to radiotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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