August 1, 2025The International Journal of NeuropsychopharmacologyOpen Access

Paternal Immune Activation via the Viral Mimic Poly I:c Leads to Epigenetic Changes in Sperm and Results in Behavioural, Brain and Physiological Changes in Offspring

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Paternal immune activation via poly I:C resulted in anxiety-related behavioural changes and altered brain parameters in offspring.
Key evidence shows altered offspring behaviours, particularly reduced time in open arms of the elevated-plus maze and slowed fear conditioning.
Assessment conducted using a cohort of C57BL/6J mice administered poly I:C; metrics included behaviour tests and immunohistochemistry analyses.
These findings support the notion that paternal environmental factors, like immune activation, may have lasting effects on offspring well-being.

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Implication

Observational analysis showed immune activation alters behaviour and brain function in offspring, highlighting potential intergenerational effects of viral mimics.

Cite This Study

Garde et al. (2025) studied this question.

synapsesocial.com/papers/68af2ee5cf1dd9ea359e6776 https://doi.org/10.1093/ijnp/pyaf052.104

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Implication

Observational analysis showed immune activation alters behaviour and brain function in offspring, highlighting potential intergenerational effects of viral mimics.

Paternal Immune Activation via the Viral Mimic Poly I:c Leads to Epigenetic Changes in Sperm and Results in Behavioural, Brain and Physiological Changes in Offspring

Key Points

Discussion

Implication

Cite This Study

Paternal Immune Activation via the Viral Mimic Poly I:c Leads to Epigenetic Changes in Sperm and Results in Behavioural, Brain and Physiological Changes in Offspring

Key Points

Discussion

Implication

Cite This Study