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July 21, 2025MicroorganismsOpen Access

Global Epidemiology and Antimicrobial Resistance of Klebsiella Pneumoniae Carbapenemase (KPC)-Producing Gram-Negative Clinical Isolates: A Review

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Authors

MFMatthew E. FalagasCAChristina-Maria AsimotouMZMaria Zidrou

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Overview

Review evaluates KPC-producing gram-negative clinical isolates across continents, highlighting global antimicrobial resistance patterns.

Key Points

  • KPC-producing gram-negative bacteria are a major global health concern due to their increasing prevalence.
  • The study included 119 articles with data across continents, identifying Klebsiella pneumoniae as the most common species.
  • Resistance to antibiotics varied, with the lowest found for ceftazidime-avibactam at 0-4% and a range of 4-80% for polymyxins.
  • Effective infection control measures and enhanced surveillance are essential to manage the spread of KPC-producing isolates.

Cite This Study

Falagas et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd2a7https://doi.org/10.3390/microorganisms13071697
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Klebsiella pneumoniae with Two Carbapenemases: Where Molecular Research Stands Now2025
  2. 2Carbapenem resistence and Carbapenemase classification of Enterobacteriaceae in Intensive Care Unit: A cross-sectional study2025
  3. 3Genotypic and Phenotypic Detection of Carbapenemase Genes in Clinical and Environmental Isolates of Klebsiella pneumoniae ST232025
  4. 4Emergence of Carbapenem-Resistant Klebsiella pneumoniae in a Romanian Infectious Diseases Hospital2025
  5. 5ANTIBIOTIC SUSCEPTIBILITY TRENDS AMONG KLEBSIELLA PNEUMONIAE ISOLATES IN CLINICAL SPECIMENS AT A TERTIARY CARE HOSPITAL2025