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July 21, 2025Open Access

The Diagnostic Utility of Prenatal Microarray in High-Risk Pregnancies: A Single-Center Experience to Enhance Reproductive Care and Risk Stratification

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Authors

ABAbdüllatif BakırMAMustafa Tarık AlayUTUmut Can Tekbaş

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Overview

Single-center analysis reveals CMA identifies 3.2% more chromosomal abnormalities, suggesting its routine use in high-risk pregnancies.

Key Points

  • MAIN FINDING: CMA identifies chromosomal abnormalities in 57 out of 344 high-risk prenatal cases, enhancing the diagnostic yield.
  • KEY EVIDENCE: Of the identified abnormalities, 11 CNVs were undetectable by conventional karyotyping, highlighting CMA's benefits.
  • APPROACH: Analysis involved 344 prenatal samples using conventional karyotyping and SNP-based CMA over a period of one year.
  • SIGNIFICANCE: Integrating CMA into prenatal care supports better risk stratification and improved reproductive outcomes for high-risk pregnancies.

Cite This Study

Bakır et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd146https://doi.org/10.20944/preprints202507.1491.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Diagnostic Utility of Prenatal Microarray in High-Risk Pregnancies: A Single-Center Experience in Enhancing Reproductive Care and Risk Stratification2025
  2. 2A retrospective study for the diagnostic value of chromosomal microarray analysis in fetuses with high-risk prenatal indications2025 · 2 citations
  3. 3Chromosomal Microarray in Prenatal Diagnosis: A Single Center Experience From Türkiye2025
  4. 4Genetic Insights from Chromosomal Microarray Analysis: The Predictive Role of Ultrasonography in High-Risk Pregnancies2025
  5. 5Diagnostic performance of chromosomal microarray and whole exome sequencing in fetal structural anomalies: a single-center retrospective study2025 · 4 citations