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August 25, 2025Frontiers in GeneticsOpen Access

A retrospective study for the diagnostic value of chromosomal microarray analysis in fetuses with high-risk prenatal indications

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Authors

HXHui XiaoShanghai Chest HospitalJXJunfang XiaoJiangxi Maternal and Child Health HospitalHZHuan ZhangSuizhou Central Hospital

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Implication

Retrospective analysis shows greater diagnostic value of chromosomal microarray analysis for prenatal diagnosis of chromosomal abnormalities, indicating improved outcomes in certain pregnancy indications.

Key Points

  • CMA identified chromosomal abnormalities in 12.11% of pregnancies, indicating its effectiveness for prenatal diagnosis.
  • The success rate of CMA was exceptionally high at 99.95%, providing reliable results for clinical samples collected.
  • Analysis of 8,560 samples revealed varied diagnostic yields based on different high-risk indications for chromosomal abnormalities.
  • CMA serves as a vital first-tier test for detecting significant structural anomalies in pregnancies, enhancing early intervention.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/68af79ab7567bf4f94ff1b28https://doi.org/10.3389/fgene.2025.1649253
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