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July 16, 2025Open Access

Convergent Cellular Adaptation to Freeze-Thaw Stress via a Quiescence-like State in Yeast

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Authors

CTCharuhansini TvishamayiFAFarhan AliNCNandita Chaturvedi

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Overview

Experimental evolution demonstrates increased freeze-thaw tolerance in Saccharomyces cerevisiae, suggesting convergence in mechanisms of microbial survival under stress.

Key Points

  • MAIN FINDING: Saccharomyces cerevisiae can evolve freeze-thaw tolerance, increasing survival from approximately 2% to about 70%.
  • KEY EVIDENCE: The adaptation occurs through a quiescence-like state characterized by increased trehalose and reduced membrane damage.
  • APPROACH: The study integrates experimental evolution and genomic analysis to examine stress adaptation in yeast under controlled conditions.
  • SIGNIFICANCE: Findings highlight a potential generalizable adaptation strategy relevant for understanding microbial survival in extreme environments.

Cite This Study

Tvishamayi et al. (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8ccd5ehttps://doi.org/10.7554/elife.106857.1
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Also Consider

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