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July 15, 2025

Supplementary Figure 11 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

QRT-PCR shows IL1R1 expression changes in esophageal squamous cell carcinoma models, indicating circTMEM45A's role in inflammation.

Key Points

  • CircTMEM45A enhances the expression of IL1R1 in esophageal squamous cell carcinoma, promoting inflammatory progression.
  • QRT-PCR and Western blot confirm increased mRNA and protein levels of IL1R1 in circTMEM45A-overexpressed cells.
  • Experimental data includes independent repetitions (n = 3) for robust statistical support of findings.
  • Understanding circTMEM45A's role could provide insights for therapeutic targets in combating esophageal cancer progression.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6c2https://doi.org/10.1158/0008-5472.29567981
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 13 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  2. 2Supplementary Figure 10 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  3. 3Supplementary Figure 6 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  4. 4Supplementary Figure 9 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  5. 5Supplementary Figure 5 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025