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July 15, 2025

Supplementary Figure 6 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

Analysis reveals circTMEM45A elevates NLRP3 and TNF levels in esophageal cancer cells, suggesting its role in inflammation.

Key Points

  • Main finding indicates that circTMEM45A facilitates inflammation in esophageal squamous cell carcinoma.
  • Key evidence shows increased NLRP3 and inflammatory markers through qRT-PCR and western blot analyses.
  • Approach included screening DEGs, conducting KEGG analysis, and measuring mRNA and protein levels in different KYSE cell lines.
  • Significance lies in understanding circTMEM45A's potential as a therapeutic target in combatting esophageal cancer progression.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc667https://doi.org/10.1158/0008-5472.29567957
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