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July 15, 2025World Journal of DiabetesOpen Access

Pharmacological management of type 2 diabetes mellitus in children and adolescents: A systematic review and network meta-analysis

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Authors

CGCharles A GagnonKBKatherine L. BuchananJDJ. MONTGOMERY DEAVER

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Overview

Network meta-analysis shows dulaglutide and dapagliflozin significantly lower HbA1c in children, indicating the need for more robust trials.

Key Points

  • MAIN FINDING: Dulaglutide, dapagliflozin, and liraglutide effectively reduce HbA1c levels in children with type 2 diabetes.
  • KEY EVIDENCE: HbA1c decreased by 1.20 for dulaglutide and 0.94 for dapagliflozin compared to control.
  • APPROACH: Analyzed data from 12 RCTs involving 1658 participants, assessing various pharmacological treatments.
  • SIGNIFICANCE: Results highlight potential effective treatments for managing type 2 diabetes in a pediatric population.

Cite This Study

Gagnon et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc551https://doi.org/10.4239/wjd.v16.i7.106890
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and Safety of GLP-1 RAs in Children and Adolescents With Obesity or Type 2 Diabetes2025
  2. 2Real-world effectiveness of sodium glucose transporter 2 inhibitors among youth with type 2 diabetes2025
  3. 3Established and emerging use of sodium-glucose cotransporter-2 inhibitors in pediatric population with type 2 diabetes: a case report and literature review2025
  4. 4Treatment With Canagliflozin Versus Placebo in Children and Adolescents With Type 2 Diabetes2025 · 1 citations
  5. 5Extinguishing the Fire: Treating Pediatric Type 2 Diabetes by Targeting Obesity Treatment.2025 · 1 citations