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September 19, 2025Journal of Pediatric Endocrinology and Metabolism

Real-world effectiveness of sodium glucose transporter 2 inhibitors among youth with type 2 diabetes

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Authors

MTMichal TimkovskiDPDhruva PatelEBElizabeth Brown

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Overview

Retrospective study shows improved HbA1c and reduced insulin use in youth with T2D using SGLT2 inhibitors.

Key Points

  • Real-world use of SGLT2 inhibitors leads to a significant decrease in HbA1c levels in youth with type 2 diabetes.
  • Among 61 participants, median HbA1c dropped from 8.4% to 7.1%, indicating effective management of blood sugar.
  • The median BMI Z-score decreased from 2.66 to 2.57, demonstrating improved weight management outcomes.
  • The percentage of patients using basal insulin reduced from 44% to 34%, suggesting lower insulin dependency.

Cite This Study

Timkovski et al. (2025) studied this question.

synapsesocial.com/papers/68d435ed713b0b5dfea75ddehttps://doi.org/10.1515/jpem-2025-0243
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