July 15, 2025Open Access

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects

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Authors

WEWorrawat Engchuan OSOmar Shanta KKKuldeep Kumar

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Implication

Multidimensional framework reveals divergent effects of genetic variations in psychiatric disorders, highlighting distinct mechanisms and implications.

Key Points

Psychiatric disorders converge on common genetic pathways but differ by diagnosis in cellular context.
Using gene-set burden analysis, significant effects of copy number variants were found across multiple diagnostic categories.
Mixed-effects modeling identified how genetic impacts vary by cell type and brain region among disorders.
Findings highlight the importance of understanding unique genetic mechanisms in different psychiatric conditions.

Cite This Study

Engchuan et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc453 https://doi.org/10.1101/2025.07.11.25331381

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Implication

Multidimensional framework reveals divergent effects of genetic variations in psychiatric disorders, highlighting distinct mechanisms and implications.

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects

Discussion

Member takes

Implication

Key Points

Cite This Study

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects

Discussion

Member takes

Implication

Key Points

Cite This Study

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