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July 14, 2025Journal of Clinical Obstetrics and Gynecology Research

Treatment Of Advanced Endometrial Cancer: A Systematic Review Of Efficacy And Safety In Clinical Trials, Molecular-Targeted Therapies And Immunotherapy.

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Authors

LPL. PinheiroTAThalita Pinheiro Morel AlineriHMHadassa Alcantu de Mauro

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Overview

Systematic review demonstrates improved overall survival with molecular-targeted therapies and immunotherapy in advanced endometrial cancer, suggesting a need for personalized treatment.

Key Points

  • Advanced endometrial cancer management is challenging but sees promise from molecular-targeted therapies and immunotherapy.
  • Estimates show that mTOR inhibitors and antiangiogenic drugs achieve objective response rates between 10% and 20%.
  • Immunotherapy with pembrolizumab demonstrated high efficacy with an objective response rate above 45% in patients with microsatellite instability.
  • Personalized treatment strategies based on molecular biomarkers can potentially improve clinical outcomes in endometrial cancer.

Cite This Study

Pinheiro et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc1e2https://doi.org/10.52338/jocogr.2025.4937
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Efficacy of Pembrolizumab Immunotherapy in the Treatment of Endometrial Cancer: A Systematic Review2025 · 4 citations
  2. 2Treatment Strategies in Advanced Endometrial Cancer: Insights on Patient Selection and Management2025
  3. 3Treatment Strategies in Advanced Endometrial Cancer: Insights on Patient Selection and Management2025
  4. 4Molecular Pharmacological Interventions for Endometrial Cancer: A Comprehensive Review2025
  5. 5Research Progress of Molecular Classification Guiding Targeted Therapy Combined with Fertility-Preserving Treatment for Endometrial Cancer2025