MR-based evaluation of cardiac strain and ejection fraction in patients with dilated cardiomyopathy and hypertrophic cardiomyopathy

Key Points

DCM patients exhibited a stronger correlation between ejection fraction and cardiac strain measures compared to HCM patients.
The analysis included 224 subjects: 99 with dilated cardiomyopathy, 98 with hypertrophic cardiomyopathy, and 27 controls.
GCS was found to have a slightly stronger correlation with ejection fraction than GLS within both the DCM and HCM groups.
Integrating strain data into routine clinical practice could enhance risk stratification in hypertrophic cardiomyopathy patients.

Abstract

Motivation: Echocardiography based cardiac strain evaluation is operative dependent. Cardiac MR is operator independent. Absence of Cardiac strain measures in Indian patient population. Goal(s): To evaluate differences in cardiac strain between patients with Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), and controls, using CMR-FT and examine its correlation with ejection fraction (EF). Approach: Retrospective cohort study analyzing clinical and imaging data from 224 subjects (98 HCM, 99 DCM, 27 controls) between 2022 and 2023. Results: DCM patients showed a stronger correlation with EF compared to HCM patients and controls. Within the DCM and HCM groups, GCS had a slightly stronger correlation with EF than GLS. Impact: This study highlights the potential of integrating strain data into clinical use as an early indicator for risk stratification, particularly in HCM patients, leading to effective interventions and improved outcomes.

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