September 17, 2025

Impaired right atrial function before right ventricle systolic dysfunction: clinical utility and prognostic value in pulmonary hypertension

Key Points

Impaired right atrial function can indicate right ventricular systolic dysfunction earlier than previously recognized.
Right atrial reservoir function serves as an independent predictor of long-term prognosis in patients with pulmonary hypertension.
Cardiac magnetic resonance imaging compares patients with and without right ventricular dysfunction to evaluate atrial function characteristics.
Detecting pulmonary hypertension early through right atrial function might prevent treatment failures and improve patient outcomes.

Abstract

Motivation: Understanding the characteristics of right atrium(RA) dysfunction before right ventricle systolic dysfunction(RVSD) is the key to take appropriate interventions and improve the prognosis of Pulmonary hypertension(PH). Goal(s): Assess the characteristics of RA function before RVSD in the early stage of PH, and evaluate its long-term prognostic significance. Approach: Cardiac morphology and functional parameters derived from cardiac magnetic resonance were compared among PH patients with and without RVSD and health controls.Cox regression analysis were also conducted. Results: RA function has the potential role in detecting the right-side heart dysfunction before RVSD and monitoring the disease progression.RA reservoir function predicts long-term prognosis independently in PH . Impact: Early detection of PH before RVSD by RA function from CMR can monitor the disease progression and long-term prognosis in patients with PH, so as to prevent treatment failure and improve the prognosis.

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