TMVR for the Treatment of Mitral Regurgitation: A State-of-the-Art Review

Key Points

Transcatheter mitral valve replacement shows promise as an alternative to surgical methods, addressing limitations associated with current treatments.
Significant residual regurgitation continues to pose challenges in treatment, with outcomes varying based on anatomic features and procedural techniques.
Observational analysis of patient selection in transcatheter mitral valve replacement reveals critical insights into effective approaches for treatment.
Challenges in developing transcatheter mitral valve replacement underscore the need for further research and innovation to improve patient outcomes.

Abstract

Mitral regurgitation is the most common valve disease worldwide. Despite its wide success in inoperable or high-risk surgical patients, transcatheter edge-to-edge repair remains limited by some anatomic features and the not negligible rate of significant residual regurgitation. Transcatheter mitral valve replacement has emerged as a viable alternative that promises to overcome these issues, but its development has been progressing slowly. This review aims to provide a comprehensive overview of the current state of transcatheter mitral valve replacement, including patient selection, procedural techniques, and currently available outcomes.

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