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September 5, 2025New England Journal of Medicine64 citations

Aspirin Discontinuation After PCI in Low-Risk Acute Myocardial Infarction Patients

Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction

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Authors

GTGiuseppe TarantiniBHBenjamin HontonVPValeria Paradies

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Overview

Randomized trial evaluates P2Y12 inhibitor monotherapy versus dual antiplatelet therapy, showing safety in low-risk patients.

Key Points

  • P2Y12-inhibitor monotherapy leads to similar adverse event rates as continued dual antiplatelet therapy.
  • Among 1942 randomized patients, primary-outcome events occurred in 2.1% receiving P2Y12 monotherapy versus 2.2% on dual therapy.
  • BARC type bleeding was significantly lower at 2.6% in the P2Y12 group compared to 5.6% in the dual therapy group.
  • Results suggest P2Y12 monotherapy may reduce bleeding risks while maintaining cardiovascular safety in low-risk patients.

Cite This Study

Tarantini et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477b973https://doi.org/10.1056/nejmoa2508808
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