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September 3, 2026Clinical Journal of the American Society of Nephrology

Intradialytic myocardial stunning emerges as an underappreciated stress cardiomyopathy and CV risk factor in hemodialysis.

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Population

People with hemodialysis-dependent kidney failure

Design

Review

Key result

This review outlines the evidence base for intradialytic myocardial stunning as a specific form of stress cardiomyopathy and an underappreciated cardiovascular risk factor in hemodialysis patients.

Authors

DCDavid M. CharytanJWJames B. WetmoreCHCharles A. Herzog

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Overview

Intradialytic myocardial stunning merits clinical vigilance in hemodialysis; review leaves open whether targeted interventions improve outcomes.

Key Points

  • To synthesize the evidence base regarding intradialytic myocardial stunning, establishing its definition, epidemiology, and pathophysiological relevance in hemodialysis-dependent end-stage kidney disease.
  • Reviewed clinical and translational literature evaluating hemodialysis-induced transient myocardial contractile abnormalities.
  • Assessed epidemiological patterns, diagnostic frameworks, and mechanistic links between intradialytic stunning and stress-mediated cardiac dysfunction such as Tako-tsubo cardiomyopathy.
  • Identifies intradialytic myocardial stunning as a form of transient contractile dysfunction induced by dialysis that closely resembles stress-induced Tako-tsubo cardiomyopathy.
  • Summarizes evidence that recurrent stunning episodes inflict cumulative cardiac damage, contributing to heart failure and cardiovascular mortality in patients on maintenance hemodialysis.
  • Defines key knowledge gaps and diagnostic avenues to guide future mechanistic studies and cardioprotective intervention strategies.

Structured PICO

P
Population
People with hemodialysis-dependent kidney failure

This review summarizes the evidence on intradialytic myocardial stunning as a potential mechanism for the high cardiovascular morbidity and mortality in hemodialysis patients.

Cite This Study

Charytan et al. (2026) conducted a review in Hemodialysis-dependent end-stage kidney disease. Intradialytic myocardial stunning was evaluated. This review outlines the evidence base for intradialytic myocardial stunning as a specific form of stress cardiomyopathy and an underappreciated cardiovascular risk factor in hemodialysis patients.

synapsesocial.com/papers/6a993511636c6408cfa7cf6bhttps://doi.org/10.2215/cjn.0000001236
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