What is the clinical evidence from this study?

Study design: Cohort. Population: End-Stage Renal Disease initiating hemodialysis (n=654). Intervention: Right ventricular systolic dysfunction vs. Absence of right ventricular systolic dysfunction. Primary outcome: Mortality (HR 1.66, 95% CI 1.34-2.06, p=<0.001).

What question did this study set out to answer?

To establish and evaluate echocardiographic criteria for identifying structural heart disease in patients with end-stage renal disease who are initiating hemodialysis.

September 2, 2026Journal of the American College of CardiologyOpen Access

Echocardiography Criteria for Structural Heart Disease in Patients With End-Stage Renal Disease Initiating Hemodialysis

Q: What are the key findings of this study?

Right ventricular systolic dysfunction independently predicted mortality among patients initiating hemodialysis (HR 1.66; 95% CI 1.34-2.06; P<0.001).

Q: What question did this study set out to answer?

To establish and evaluate echocardiographic criteria for identifying structural heart disease in patients with end-stage renal disease who are initiating hemodialysis.

View Full Paper

Ask AI

Bookmark

Key result

Right ventricular systolic dysfunction predicts ~66% higher mortality among patients initiating hemodialysis.

HR 1.66
95% CI 1.34-2.06
P<0.001
n=654

Key Points

To establish and evaluate echocardiographic criteria for identifying structural heart disease in patients with end-stage renal disease who are initiating hemodialysis.
Assessed cardiac structure and function using standard echocardiographic imaging protocols in patients with end-stage renal disease at the onset of hemodialysis therapy.
Echocardiographic measurements define specific thresholds for structural abnormalities, including chamber enlargement and ventricular remodeling, in patients transitioning to maintenance hemodialysis.

Study Design

Type

Cohort (n=654)

PICO

Population

654 patients (mean age 66, 60% male) initiating chronic hemodialysis who underwent echocardiography near initiation, followed for a median of 2.4 years.

Exposure / Comparator

Right ventricular systolic dysfunction vs Absence of right ventricular systolic dysfunction

Primary Outcome

Mortality — HR 1.66 (1.34-2.06), p=<0.001

Main Result

Hazard Ratio: 1.66 (95% CI 1.34–2.06)

p-value: p=<0.001

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Clinical evaluation reveals echocardiographic criteria for structural heart disease in patients with end-stage renal disease, highlighting cardiac risk at hemodialysis initiation.

Cite This Study

Hickson et al. (2016) conducted a cohort in End-Stage Renal Disease initiating hemodialysis (n=654). Right ventricular systolic dysfunction vs. Absence of right ventricular systolic dysfunction was evaluated on Mortality (HR 1.66, 95% CI 1.34-2.06, p=<0.001). Right ventricular systolic dysfunction independently predicted mortality among patients initiating hemodialysis (HR 1.66; 95% CI 1.34-2.06; P<0.001).

synapsesocial.com/papers/6a983e54e2c3f4e5c6dba747 https://doi.org/10.1016/j.jacc.2015.12.052

View Full Paper

Ask AI

Bookmark

Implication

Clinical evaluation reveals echocardiographic criteria for structural heart disease in patients with end-stage renal disease, highlighting cardiac risk at hemodialysis initiation.

Echocardiography Criteria for Structural Heart Disease in Patients With End-Stage Renal Disease Initiating Hemodialysis

Key Points

Study Design

PICO

Main Result

Discussion

Implication

Cite This Study

Echocardiography Criteria for Structural Heart Disease in Patients With End-Stage Renal Disease Initiating Hemodialysis

Key Points

Study Design

PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider