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September 2, 2026BiomedicinesOpen Access

Physical Exercise and Angiotensin II Receptors: A Systematic Review

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Why the study?

Does physical exercise alter the expression of angiotensin II receptors (AT1R and AT2R)?

Population

11 studies (10 experimental animal models and 1 involving humans)

Design

Systematic_review

Key result

Chronic cyclic physical exercise was associated with reduced AT1R expression and increased AT2R expression in various tissues, whereas resistance exercise increased AT1R expression.

Authors

AOAlice Miranda de OliveiraNSNataniele Santana de SouzaLRLidiane Canuto Rodrigues

Discussion

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Overview

Exercise may favorably modulate RAS balance; extends preclinical insights but leaves clinical translation open.

Key Points

  • To systematically review and compile evidence on the effects of physical exercise on the expression of angiotensin II receptors (AT1R and AT2R) within the renin–angiotensin system.
  • Conducted a systematic review registered in PROSPERO (CRD420251267388) across PubMed/MEDLINE, PEDro, Cochrane CENTRAL, SciELO, LILACS, Web of Science, and Scopus databases.
  • Evaluated risk of bias using the RoB 2 tool for human studies and SYRCLE for animal studies.
  • Screened 724 identified records to include 11 eligible studies (10 animal experimental models and 1 human study).
  • Chronic cyclic physical exercise was consistently associated with reduced expression of AT1R and elevated expression of AT2R across multiple body tissues in experimental models.
  • Resistance exercise demonstrated a distinct physiological profile in the single study evaluating it, showing an increase in AT1R expression.
  • The synthesized evidence on receptor modulation is derived almost entirely from animal models, with only one human study meeting eligibility.

Study Design

Type

Systematic Review (n=11)

Structured PICO

Does physical exercise alter the expression of angiotensin II receptors (AT1R and AT2R)?

P
Population
11 studies (10 animal models and 1 human study) evaluating the effect of physical exercise on angiotensin II receptor expression.
I
Intervention
Physical exercise (including chronic cyclic physical exercise and resistance exercise)
O
Outcome
Expression of angiotensin II receptors (AT1R and AT2R) within the renin-angiotensin systemsurrogate

Chronic cyclic physical exercise may beneficially modulate the renin-angiotensin system by reducing AT1R and increasing AT2R expression, though current evidence is largely preclinical.

Limitations

  • The evidence is derived primarily from animal studies.
  • Evidence is derived primarily from animal studies

Cite This Study

Oliveira et al. (2026) reported a systematic review. Physical exercise was evaluated on Expression of angiotensin II receptors (AT1R and AT2R). Chronic cyclic physical exercise was associated with reduced AT1R expression and increased AT2R expression in various tissues, whereas resistance exercise increased AT1R expression.

synapsesocial.com/papers/6a97e249c562ede874ec64a3https://doi.org/10.3390/biomedicines14091956
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