Why the study?
Does a high-fat diet induce metabolic inflammation and cardiac remodeling through gut microbiota alterations in mice?
Population
12 six-week-old male C57BL/6J mice
Comparison
High-fat diet containing 60% kcal from fat, 20%… vs Normal chow diet containing 10% kcal from fat…
Design
Preclinical, randomly assigned to two groups
Follow-up
16 weeks
Key result
A high-fat diet induced metabolic syndrome, systemic inflammation, and early cardiac remodeling in mice, which was associated with significant gut microbiota dysbiosis and functional reprogramming.
Authors
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Taxa identified in MetS mouse models may inform human studies; leaves open clinical translation of microbiota interventions.
Does a high-fat diet induce metabolic inflammation and cardiac remodeling through gut microbiota alterations in mice?
A high-fat diet induces metabolic syndrome and early cardiac remodeling in mice, which is associated with gut microbiota dysbiosis and functional reprogramming.
Feng et al. (2026) studied Metabolic syndrome (n=12). High-fat diet vs. Standard chow diet was evaluated on Metabolic parameters, cardiac remodeling, and gut microbiota composition. A high-fat diet induced metabolic syndrome, systemic inflammation, and early cardiac remodeling in mice, which was associated with significant gut microbiota dysbiosis and functional reprogramming.