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August 27, 2026Journal of Functional FoodsOpen Access

Investigation of the regulatory mechanisms of Zanthoxylum armatum extract on inflammatory responses and lipid metabolism dysregulation in human keratinocytes

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Authors

LMLei MaXZXueying ZhengJJJiaru Jiang

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Overview

In vitro study demonstrates that Zanthoxylum armatum extract reduces inflammation and lipid accumulation in keratinocytes, highlighting its multi-target therapeutic potential for acne vulgaris.

Key Points

  • To investigate the therapeutic effects and molecular mechanisms of ethanolic Zanthoxylum armatum extract on inflammatory responses and dysregulated lipid metabolism in keratinocytes.
  • Profiled extract constituents using UPLC-Q-TOF-MS and prioritized central molecular targets via network pharmacology and molecular docking.
  • Evaluated the biological effects of the extract in LPS/TNF-α-stimulated HaCaT human keratinocytes.
  • Extract treatment significantly downregulated the mRNA expression of pro-inflammatory cytokines, including IL-17A, IL-6, IL-8, and TNF-α, while mitigating cellular oxidative stress.
  • Extract administration reduced cellular lipid accumulation by activating the PPARα pathway and suppressing SREBP-1-mediated lipogenesis.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a8fea3310c91c1e926224e1https://doi.org/10.1016/j.jff.2026.107473
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